We publish multidisciplinary research spanning the biological & chemical sciences
New Preprints
G. Lutfullahoglu Bal, K.-Y. Ng, E. Berzell, A. Akpinar, A.E. Ekvik, L. Koludarova, S. Naddafi, C. Rath, T. Vane-Tempest, J.J. VanPortfliet, S. O'KEEFE, A.K. Najumudeen, T.A. Nyman, J.B. Stewart, P.A. West, B.J. Battersby. 2025. Intrinsic errors during mitochondrial protein synthesis trigger a decline in cell fitness. BioRxiv. doi: 10.1101/2025.10.13.682189. Accepted at Nature Communications.
P.K. Raval, C. Mitchell, M. Lozano-Quiles, S. O'KEEFE, T.A. Nyman, B.J. Battersby, S.J. Butcher, S.B. Gould. 2026. Rapid plastid isolation reveals the chloroplast proteome and structures of the chlororibosome large subunit and RuBisCO in Marchantia polymorpha. BioRxiv. doi: 10.1101/2025.10.13.682189. In Revision.
10 Selected Publications
J. Chang, A. Pickard, J.A. Herrera, S. O’KEEFE, M. Hartshorn, R. Garva, A. Hoyle, L. Dingle, C. Zeltz, J. Wong, A. Reid, R.V. Venkateswaran, Y. Lu, P. Caswell, S. High, D. Gullberg, K.E. Kadler. 2024. Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis. eLife. 13:RP9542.
H. Stewart, Y. Lu, S. O’KEEFE, A. Valpadashi, L.D. Cruz-Zaragoza, H.A. Michel, S.K. Nguyen, G.W. Carnell, N. Lukhovitskaya, R. Milligan, Y. Adewusi, I. Jungrels, V. Lulla, D.A. Matthews, S. High, P. Rehling, E. Emmott, J.L. Heeney, A.D. Davidson, J.R. Edgar, G.L Smith, A.E. Firth. 2023. The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity. iScience. 26:108080
A.B. Schäfer, M. Steenhuis, K. Jim, S. O’KEEFE, R.C. Whitehead, E. Swanton, B. Wang, S. Halbedel, S. High, J. van Dijl, J. Luirink, M. Wenzel. 2023. Dual action of eeyerestatin 24 on Sec-dependent protein secretion and bacterial DNA. ACS Infectious Diseases. 9:253-269
S. O'KEEFE, M.R. Pool, S. High. 2022. Membrane protein biogenesis at the ER: the highways and byways. FEBS Journal. 289:6835-6862
S. O’KEEFE, G. Zong, K.B. Duah, L.E., Andrews, W.Q. Shi, S. High. 2021. An alternative pathway for membrane protein biogenesis at the endoplasmic reticulum. Communications Biology. 4:828
S. O’KEEFE, R. Roboti, K.B. Duah, G. Zong, H. Schneider, W.Q. Shi, S. High. 2021. Ipomoeassin F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor. Journal of Cell Science. 134: jcs.257758
G. Zong, Z. Hu, S. O’KEEFE, D. Tranter, M.J. Ioannotti, L. Baron, B.S Hall, K. Corfield, A. Paatero, M. Henderson, P. Roboti, J. Zhou, X. Sun, M. Govindarajan, J.M. Rohde, N. Blanchard, R. Simmonds, J. Inglese, Y. Du, C. Demangel, S. High, V.O. Paavilainen, W.Q. Shi. 2019. Ipomoeassin F binds to Sec61α to inhibit protein translocation. Journal of the American Chemical Society. 141:8450-8461.
S. O’KEEFE, Q.P. Roebuck, I. Nakagome, S. Hirono, A. Kato, R. Nash, S. High. 2019. Characterizing the selectivity of ER α-glucosidase inhibitors. Glycobiology. 29: 530–542
I. Gamayun, S. O’KEEFE, T. Pick, M-C. Klein, D. Nguyen, C. McKibbin, M. Piacenti, H.M. Williams, S.L. Flitsch, R.C. Whitehead, E. Swanton, V. Helms, S. High, R. Zimmermann, A. Cavalié A. 2019. Eeyarestatin compounds selectively enhance sec61-mediated Ca2+ leakage from the endoplasmic reticulum. Cell Chemical Biology. 26:571-583
M. Javanainen, J. Šimek, D. Tranter, S. O’KEEFE, S. Karki, D. Biriukov, R. Šachl, V.O. Paavilainen. 2025. Lipid scrambling pathways in the Sec61 translocon. Journal of the American Chemical Society. 147:15970-15984
